THE EFFECT OF CANDESARTAN PRE-STROKE USE ON THE FUNCTIONAL OUTCOME OF POST ISCHEMIC STROKE PATIENTS IN BETHESDA HOSPITAL YOGYAKARTA
Abstract: Stroke is a leading
cause of death and disability, where the main risk factor is hypertension.
Angiotensin Receptor Blocker (ARB) is the most common drug for stroke
prevention in high-risk hypertensive patients. The purpose of this study was to
see whether the candesartan pre-stroke use can improve the functional outcomes
of post ischemic stroke patients. The data were obtained from 191 retrospective
observational studies. Data were collected from Stroke Registry and medical
record at Bethesda Hospital Yogyakarta in 2014-2016, then analyzed univariate,
followed by bivariate analysis using chi-square test, independent t-test and
fisher exact test for the variable which has actual count (F0), and logistic
regression for multivariate analysis. One hundred and ninety one samples were
systematically reviewed to evaluate the effect of candesartan pre-stroke use on
functional outcomes of post ischemic stroke patients in Bethesda hospital
Yogyakarta whose range of ages was mostly between 61 and 70 years (30.9%) and were
mostly male patients (56.5%). Patients with good functional outcomes (<2)
were 79.6% and poor functional outcomes (≥2) were 20.4%. The results of
bivariate analysis showed that candesartan did not affect the improvement of
clinical outcome (OR: 1.806, 95% CI: 0.591-5.519, p: 0.294), and also not
better than other angiotensin receptor blocker (p=0.505, OR=1.472, 95% CI=
0.470-4.611). The multivariate analysis showed that sex (OR: 0.366, 95% CI:
0.156-0.858, p: 0.021), loss of consciousness (OR: 0.107, 95% CI: 0.021-0.549,
p: 0.007), limb weakness (OR: 0.236, 95% CI: 0.067-0.834, p: 0.025),
dyslipidemia comorbidity (OR: 2.750, 95% CI: 1.177-6.427, p: 0.019) and aphasia
(OR: 0.342, 95% CI: 0.107-1.100, p: 0.072) affected the functional outcome. The
candesartan pre-stroke use did not improve the functional outcome of post
ischemic stroke patient.
Keywords: angiotensin receptor
blocker; candesartan; functional outcome; ischemic stroke; neuron protection
Penulis: Lise Insani Gulo,
Rizaldy Taslim Pinzon, Esdras Ardi Pramudita
Kode Jurnal: jpfarmasidd180154
