STUDI FARMAKOFOR RESEPTOR ESTROGEN α SEBAGAI TARGET TERAPI KANKER SERVIKS
Abstrak: One of the target on
chemotherapeutic agent especially for curing cervical cancer is the inhibition
of estrogen activity on estrogen alpha receptors. Estrogen stimulates human
papilloma virus oncogene expression, promotes cervical cancer (CC) cell
proliferation and prevents apoptosis. Therefore, blockage of estrogen function
may have therapeutic application to CC.
SERMs (Selective Estrogen Receptor Modulator) are the group of subtances
which inhibit the activity of estrogen on its receptor. The aim of this
reserach is to determine the features that are important pharmacophore on
anti-cercix cancer activity of compounds on ER-α receptor that depended on this
receptor. Modeling and determination pharmacophore features created using the
program MOE application version 2009. Screening Virtual of chemical compounds
to look for natural ingredients in accordance with pharmacophore features that
have been made, performed using MOE. The result of the pharmacophore showed that
4-hydroxitamoxifen and its analogues have an antagonism activity on estrogen
alpha receptor.
KATA KUNCI: ER-α., cervix
cancer., 4-hydroxitamoxifen., pharmacophore
Penulis: Nursalam Hamzah,
Ahmad Najib, Fatmawati S
Kode Jurnal: jpfarmasidd140551
