Formulasi dan Karakterisasi Nanokapsul Asiklovir Tersalut Kitosan-Alginat yang Dipaut Silang dengan Natrium Tripolifosfat
Abstrak: Formulation and
characterization of chitosan-alginate crosslinked with sodium tripolyphosphate
as coating agents acyclovir nanocapsule purposed to determine how the
comparison the coating of chitosan and sodium alginate crosslinked with sodium
tripolyphosphate produce the best nanocapsule characteristics based on
morphological observations and encapsulation efficiency. Nanocapsule
formulation by the ionic gelation method by using chitosan concentrates
variation on formula A, B, and C in succession 1.5%, 1.75%, and 2%, sodium
alginate 0.5%, 0.625%, and 0.75% with stable concentration of sodium
tripolyphosphate is 5%. Nanocapsule was measured using UV-Vis spectrophotometer
at a wavelength of 297 nm with encapsulation efficiency obtained from the
formula A, B and C, respectively for 58.5%; 87.25% and 55.25%. Observation of
the shape and size of nanocapsule performed using SEM. Formula B with
concentration of chitosan 1.75%, sodium alginate 0.625% and sodium
tripolyphosphate 5% has the best characteristics with the encapsulation
efficiency 87.25%, that the smallest particle size was 200 nm and the largest
particle size was 4500 nm.
KATA KUNCI: Nanocapsule.,
Acyclovir., Chitosan., Alginate., Sodium Tripolyphosphate
Penulis: Isriany Ismail,
Hasriani Hasriani, Surya Ningsi
Kode Jurnal: jpfarmasidd140552
