OPTIMASI NANOKAPSUL ASPIRIN YANG TERSALUT KITOSAN– GOM GUAR YANG DIPAUT SILANG DENGAN NATRIUM TRIPOLIFOSFAT
Abstrak: A researched has been
done about optimation of chitosan – guar gum crosslinked with sodium
tripolyphosphate as coating agents nanocapsule aspirin. The researched purposed
to get the best coating aspirin adsorption is based from observation of
morpology and effisiency encapsulation.
Nanocapsule formulations made with ionic gelation methods, using
variation concentration of chitosan (1,5%, 1,75%, 2%), guar gum (0,75%, 0,55%,
0,35%), with fixed concentration of sodium tripolyphosphate (5%). Nanocapsules
aspirin was measured using UV-Vis Spectrophotometry at a wavelength of 287 nm.
Observation of the shape and size of the particles was performed using SEM
(Scanning Electron Microscope). Encapsulation Effisiency obtained from formula
A, B, and C of 28%, 52,6%, and 31,2%. Formula with chitosan concentration
1,75%, 0,55% guar gum, and 5% sodium tripolyphosphate (Formula B) has the best
characteristics of the encapsulation effisiencyof 52,6%, the not sferis shape
of the particles and more uniform thet the smallest particles size was 400 nm
and the largest particle size was 2400 nm.
KATA KUNCI: Cellulite.,
Caffeine., Patch., In Vitro Penetration Testing., Releasing Profil
Penulis: Surya Ningsi, Ismail,
Andi Ulfiana Utari
Kode Jurnal: jpfarmasidd140550
