Formation of Andrographlolide-Beta-Cyclodextrin Inclusion to Increase Solubility and Dissolution Rate
Abstrak: Andrographolide (AG)
is a pure isolate of the chemical synthesis of sambiloto (Andrographis
paniculata Nees.) which has various pharmacological properties such as
anti-inflammatory and antimicrobial. In order to improve the ability of AG to
penetrate the membrane in transdermal use, an inclusion complex was formed
using beta-cyclodextrin (BCD) by modifying the physical chemistry properties of
AG, particularly the solubility in its base, partition, and distribution on the
skin, as well as by changing the permeability of the stratum corneum. The
inclusion complexes of AG with BCD were prepared by the solvent evaporation
method in the mole ratios of 1:1, 1:2, and 2:1. The solid of the yield of AG
inclusion complex in BCD has been tested with a solubility test until it
reached equilibrium at 37 ± 5 °C for 24 hours and In vitro dissolution rate
test using the II USP method (paddle type), then compared to a single AG
compound, and a physical mixture of AG-BCD. Based on the solubility and
dissolution rate tests, it showed that the formation of AG-BCD inclusion
complex was obtained at the mole ratio of 1:2. Moreover, the AG solubility
increased 38 timesand the dissolution rate in the 60th minute increased twice in the inclusion complex with BCD.
Key words: andrographolide,
inclusion complex, beta cyclodextrin, solubility, dissolution rate
Penulis: Bayu Febram Prasetyo,
Ietje Wientarsih, Dondhin Sajuthi, Vetnizah Juniantito
Kode Jurnal: jpfarmasidd180223
