The Difference of Gastric pH in Dyspepsia Patients With or Without Type 2 Diabetes Mellitus
Abstract: Dyspepsia syndrome
often experienced by patients with diabetes mellitus (DM). Gastric acid is one
of the aggressive factors of syndrome dyspepsia and peptic ulcers. This study
aims to find the difference of gastric pH in dyspepsia patients with DM and
without DM, and also to determine whether there is any correlation between
gastric pH with proteinuria and hemoglobin A1c (HbA1c).
Method: Two groups of patients consisted of 30 patients with DM and 30
patients without DM. Basal gastric pH of each group counted. Basal gastric pH
was measured by inserting electrode catheter into the stomach for 30 minutes
and then recorded on PH Metri brand Digitrapper pH-Z. Complication of DM was
measured by microalbuminuria, while blood sugar control was measured by HbA1c.
Chi-square test was done to look for difference of gastric pH between the
diabetic patients group and non-diabetic patients group, by first determining
the point of intersection with receiver operating characteristic (ROC)
analysis. Correlation test between basal gastric pH with microalbuminuria and
HbA1c were done.
Results: Basal gastric pH in dyspepsia patients with DM vs. dyspepsia
patients without DM was 2.30 ± 0.83 vs. 2.19 ± 0.52. With the Chi-square test,
there is a significant difference between the diabetic patients group and
non-diabetic patients group. With the correlation test between gastric pH and
microalbuminuria was found r = 0.47 and p < 0.05, whereas the correlation
test between gastric pH and HbA1c was found r = 0.59 and p > 0.05.
Conclusion: There is a significant difference between basal gastric pH in
diabetic dyspepsia patients and non-diabetic dyspepsia patients. There is a
correlation between basal gastric pH and microalbuminuria, whereas there is no
correlation between basal gastric pH and HbA1c.
Keywords: basal gastric pH;
dyspepsia; diabetes; microalbuminuria; HbA1c
Author: Ilum Anam, Ari Fahrial
Syam, Dante Saksono Harbuwono
Journal Code: jpkedokterangg150436
