Gastric Mucous Atrophy and Metaplasia in Patient with Helicobacter pylori Infection
Abstract: Helicobacter pylori
(H. pylori) is one of the most common bacteria found in human and cause chronic
infection. Recent study conducted in one of private hospitals in Jakarta shows
that there is a trend of declining prevalance of H. pylori from 12.5% in 1998
to 2.9% in 2005. The aim of this study is to obtain` the prevalance of gastric
atrophy and metaplasia in patients with H. pylori infection based on
histopathology.
Method: This was a case control study between June to August 2014 with 69
cases and 71 controls using medical records datas and histopathology results.
Control sample was taken consecutively from patient undergone
esophagogastroduodenoscopy procedure in 2013.
Results: The average age for patient with H. pylori was 51 years slightly
higher than patient with negative H. pylori (p > 0.05). Generally, the
prevalence rate among males was slightly lower than females (p > 0.05). From
Histopathology findings, active chronic gastritis was found in 62.3% patients
with positive H. pylori than only 12.7% in patient with negative H. pylori (95%
CI = 4.86-26.7; OR = 11.31). Mild and moderate
atrophy was higher among H. pylori positive (p = 0.09). gastric mucous
metaplasia was also higher (10% vs. 1.4%) among positive H. pylori patient (p =
0.03).
Conclusion: H. pylori infection can cause atrophy and metaplasia in
gastric mucosa. Prevalence of gastric metaplasia caused by H. pylori infection
is lower in this study compared to the same study abroad.
Keywords: H. pylori;
histopathology; mucosal atrophy; metaplasia
Author: Nikko Darnindro, Ari
Fahrial Syam, Diah Rini Handjari, Dadang Makmun
Journal Code: jpkedokterangg150437
