Relationship between Metformin and Frailty Syndrome in Elderly People with Type 2 Diabetes
Abstract: to explore the
possibility of metformin protective effect on frailty syndrome. Methods: this
was a case control study conducted in subjects’ ≥60 years old who visited the
Geriatrics and Diabetes outpatient clinic of Cipto Mangunkusumo National
Referral Hospital between March and June 2013. Diagnosis of frailty was
established using the FI-40 item criteria. Statistical analysis was done with
chi-square method for bivariate and logistic regression method in multivariate
analysis, all data was accompanied with 95% confidence interval. Results:
frailty syndrome was found in 25% of subjects (n=59), with median age of 72
years old (SD 6.27) and median of FI-40 item score was 0.18 (SD 0.085).
Metformin was found to have a significant relationship with frailty syndrome in
the elderly diabetics, which retained significant value after multivariate
analysis (adjusted OR 0.043; 95% CI 0.019-0.099; p<0.001). Conclusion:
metformin was shown to have protective effect against frailty syndrome in
elderly diabetics.
Key words: frailty, diabetes
mellitus, metformin, elderly.
Author: Stevent Sumantri, Siti
Setiati, Dyah Purnamasari, Esthika Dewiasty
Journal Code: jpkedokterangg140320
