Profile and Factors Associated with Mortality in Mediastinal Mass During Hospitalization at Cipto Mangunkusumo Hospital, Jakarta
Abstract: to obtain
characteristics, variations of the type of mass, diagnostic modalities, and
mortality factors during hospitalization in patients with mediastinal mass at
our institute during a 10-year period. Methods: a case-control study was conducted,
by browsing through the medical records of 113 mediastinal mass patients who
were treated at Cipto Mangunkusumo Hospital, Jakarta, during a 10-year period
(January 2000-December 2009). Factors associated with mortality, i.e; sepsis,
septic shock, pneumonia, lung tuberculosis, superior vena cava syndrome,
massive pleural effusion, pericard effusion, and respiratory failure were
analyzed by logistic regresion multivariate analysis. Results: two hundred and
one mediastinal mass patients were diagnosed and treated at our institute, 113
medical records were available to be included in this study. There were 69
males and 44 females with the age range of 18-60 years. One-hundred and seven
patients were symptomatic at presentation. Mediastinal tumor was the most
common mediastinal mass found among the subjects. The most frequent mass
location was in the anteriosuperior compartement. Chest X-ray imaging were able
to detect 61 cases of mediastinal mass, while 42 patients underwent thoracotomy
(open biopsy) to acquire histopathology diagnosis. The proportion of mortality
during hospitalization reached 39.8%. Logistic regression multivariate analysis
found sepsis (p=0.000), superior vena cava syndrome (p = 0.000), and massive
pleural effusion (p=0.047), were significant factors associated with mortality
during hospitalization. Conclusion: the clinical and radiologic features of
mediastinal mass patients in our institute showed that mediastinal mass may
resemble the symptoms of other diseases. Types and diagnostic modalities
performed in our study differs from other studies previously reported in other
countries with a high proportion of mortality during hospitalization.
Key words: mediastinal mass,
sepsis, superior vena cava syndrome, massive pleural effusion
Author: Gurmeet Singh,
Zulkifli Amin, Wuryantoro, Valy Wulani,
Hamzah Shatri
Journal Code: jpkedokterangg130275
