TRIAMCINOLONE ACETONIDE AND 5-FLUOROURACIL INTRALESIONAL COMBINATION INJECTION IN KELOID TREATMENT
ABSTRACT: To evaluate the
effectiveness of steroid and 5-fluorouracil (5-FU) injection combination for
keloid management.
Methods: A 22-year-old female patient was presented with recurrent skin
lesions. The skin lesions first appeared 10 years prior to consultation, had
been surgically excised, and were given triamcinolone acetonide injection.
However, no improvement was observed. A decision was made to use and evaluate treatment
using an intralesional 4 mg (0.1 ml of 40 mg/ml) triamcinolone acetonide and 45
mg (0.9 ml of 50 mg/ml ) 5-FU injection combination for 5 weeks.
Results: Clinical improvements were observed in the third week as the
lesions softened and pruritic sensation dinimished. At the end of the fifth
week, improvements in the form of keloid lesion flattening and size reduction
were observed.
Conclusions: Intralesional injection using a combination of triamcinolone
acetonide and 5-fluorouracil is effective for keloid lesion treatment.
Keywords: 5-fluorouracil,
intralesional injection, keloid, triamcinolone acetonide
Penulis: Jono Hadi Agusni, Eva
Krishna Sutedja, Franky Chandra
Kode Jurnal: jpkedokterandd170219
