THE EFFICACY OF DUTASTERIDE AND GREEN TEA TOWARDS BLEEDING ON BPH AFTER TURP: STUDY THEIR EFFECT ON HIF-1α EXPRESSION & HEMATOCRIT
Abstract: This study proves
differentiation of the combination of dutasteride and green tea, dutasteride,
green tea, and placebo alone and their association with differences in
hematocrit levels and the expression of hypoxia induced factor-1 alpha (HIF-1α)
in patients with Benign Prostate Hyperplasia (BPH) were performed Trans
urethral resection of the prostate (TURP) surgery. Material & method:
Experimental study with the draft "randomized control trial". Comparing
angiogenesis changes between groups of BPH patients who underwent TURP surgery
to assess the expression of HIF-1α and Δ Ht (Hematocrit) after administration
of dutasteride, green tea with combination of dutasteride and green tea for 14
days. Results: The combination of dutasteride and green tea was not significant
in reducing the expression of HIF-1α. Mean P1 group (59.32 ± 14.69); P2 group
(59.11 ± 20.73); P3 group (64.21 ± 14.95); K group (58.16 ± 16.00). Kruskal
test results obtained p=0.491 walis which means the difference percentage of
HIF-1α among the 4 groups was not significant. The mean Δ Ht P1 group (0.61 ±
0.204); P2 group (0.54 ± 0.250); P3 group (0.41 ± 0.275); group K (0.41 ±
0.275). In statistical test with Mann Whitney test comparing the percentage
reduction obtained Ht levels dutasteride group against group of green tea
obtained p=0.213 means that there is no significant difference. Where a
significant difference to the other groups. Conclusion: The combination of
dutasteride and green tea for 14 days before TURP surgery does not reduce the
expression of HIF-1α in BPH patients who underwent TURP surgery. Δ Ht
significant decline in the combination group compared with other groups and
might be influenced by several factors during TURP surgery.
Keywords: HIF-1α; hematocrit;
benign prostate hyperplasia; dutasteride; green tea
Author: Andry Irawan, Ignatius
Riwanto, Eriawan Agung Nugroho
Journal Code: jpkedokterangg170022
