PROGNOSTIC FACTORS OF RENAL CANCER
Abstract: Course of the
disease of kidney cancer may be unpredictable. For example, between 4.2–7.1% of
patients with tumours ≤4 cm that are usually slow-growing may have metastases
at diagnostic and are at an elevated risk of disease-specific mortality. Conversely,
as many as 40% of patients with lymph node metastases were diagnosed at
nephrectomy are alive 5 year after surgery. Several approaches have been
proposed to help predict the course of disease of kidney cancer and to
distinguish between poor and favourable risk patients. In this study, we review
the existing prognostic factors and compared with established prognostic
models. Material & methods: This is an analytic descriptive study of all
kidney cancer patients treated at Haji Adam Malik Hospital between 2011 and
2015. Individual patient data was collected from medical record and compiled.
Results: The number of samples analyzed in this study were 38 patients. We
found seven patients remain alive of the entire sample. From the results of the
univariate test, the factors that have a significant relationship with the
mortality rate were low KPS (<80), weight loss, and nephrectomy. From the
results of multivariate analysis, nephrectomy is the only prognostic factor in
patients with kidney cancer. Mortality rate was 0.056x lower in patients who
underwent nephrectomy compared with patients who did not underwent nephrectomy.
Conclusion: Despite the high mortality rate that is found in this study,
nephrectomy still has a place in kidney cancer management, even in patients
with advanced stage.
Keywords: kidney cancer
Author: Riyan Adi Kurnia, Syah
Mirsya Warli, Ginanda Putra Siregar
Journal Code: jpkedokterangg170024
