THE EFFECT OF ANDROGEN DEPRIVATION THERAPY ON THE LIPID PROFILE AND BLOOD GLUCOSE LEVEL IN PROSTATE CANCER PATIENTS IN ADAM MALIK GENERAL HOSPITAL MEDAN
Abstract: The aim of this
study is to observe the effect of Androgen Deprivation Therapy (ADT) on
patients with advanced stage of prostate cancer on the lipid profile and blood
glucose level. Material & Methods: This is a descriptive cross-sectional
study and include the prostate cancer patients which were admitted to Urology
Policlinic in Haji Adam Malik General Hospital, Medan from June 2014 – June
2015 and also received ADT. Results: From June 2014 – June 2015, a total of 25
prostate cancer patients receiving ADT was included in this study with an
average age of 67.08 ± 7.48 years old. The median prostate specific antigen
(PSA) level of this group of patients is 19.6 ng/mL and the lowest and highest
value of 3.4 and 278 ng/mL respectively. ADT administration is found to cause a
significant elevation of 2-hour postprandial blood glucose (121.12 ± 21 mg/mL
vs 134.64 ± 33.35 mg/mL, p-value=0.011) and Glycosylated hemoglobin (5 ± 0.5% vs
5.5 ± 0.79%, p-value=0.000) (HbA1c) after 6 months of therapy. Additionally,
ADT administration within 3 and 6 months of duration had also significantly
increased triglyceride (TG) level when compared to before treatment (104.4 ±
38.67 vs 131.2 ± 32.27 vs 127 ± 33.43 respectively, p-value=0.005). Conclusion:
ADT treatment in prostate cancer patients increase triglyceride levels after 3
and 6 months of treatment followed by 2-hour postprandial blood glucose and
HbA1C levels after 6 months of the treatment.
Keywords: Prostate cancer;
androgen deprivation therapy; Haji Adam Malik General Hospital
Author: Willi Irawan, Syah
Mirsya Warli
Journal Code: jpkedokterangg170021
