THE EFFECT OF COMBINED α1-ADRENERGIC BLOCKERS AND PDE-5 INHIBITORS THERAPY ON IPSS, IIEF-5, QMAX AND PVR PATIENTS BPH WITH LUTS AND ERECTILE DYSFUNCTION
Abstract: Assess the efficacy
of combined α1-adrenergic blocker (tamsulosin 0,4 mg) and PDE5 inhibitor
(tadalafil 5 mg) therapy compared to tadalafil or tamsulosin alone in treating
patient BPH with LUTS and ED.
Material and methods: A randomised, double blind experimental study
assessed 36 sexually active men with ED and LUTS suggestive of BPH. All patients were randomized to 3 groups:
tamsulosin 0,4 mg (n=12), tadalafil 5mg (n=12), and combination of tamsulosin
0,4 mg and tadalafil 5 mg (n= 12), once daily for 6 weeks. Changed in IPSS scores and QoL index, IIEF-5
scores, Qmax, PVR and blood pressure were assessed and compared to baseline.
Complication and serious adverse event were also monitored. Outcomes were assessed using ranked analysis
of variance (ANOVA) and Kruskall-Wallis depends on data distribution and
homogenity.
Results: Tamsulosin 0,4 mg once
daily for 6 weeks were significantly improved IPSS score and QoL index and Qmax
from baseline. Tadalafil 5 mg once daily
for 6 weeks were significantly improved IPSS score, QoL index and IIEF-5 index
from baseline. Combined tamsulosin and tadalafil therapy were significantly
improved IPSS score, QoL index, IIEF-5 index and Qmax from baseline. Significantly better improvement on IIEF-5
dan Qmax from baseline were observed on the combination of tamsulosin and
tadalafil compared to monotherapy with tamsulosin or tadalafil after 6 weeks
in patients BPH with LUTS and erectile
dysfunction. There was no significant decreased in systolic and diastolic blood
pressure from combined treatment compared to single treatment.
Conclusions: Combined tamsulosin and tadalafil therapy was significantly
better in improving IIEF a
Keywords: BPH; LUTS; erectile
dysfunction; α1-adrenergic blocker; PDE-5 inhibitor
Author: Muhammad Ridha,
Sunaryo Hardjowijoto, Johan Renaldo
Journal Code: jpkedokterangg170035
