Starfruit Leaves as Glucose Absorption Inhibitor in Mice’s Small Intestinal Epithelial Cells
Abstract: Starfruit (Averrhoa
carambola) leaves contain flavone derivatives that exhibit anti-hyperglycemic
effects. This study aims to determine the effect of starfruit leaves in
reducing glucose absorption in intestinal epithelial cells of mice. Methods:
This study was done by performing perfusion on the small intestines of mice.
The mice that were used in this study were divided into four groups. The
control group was given glucose solution without infused starfruit leaves
whereas, the remaining 3 groups were given 3 mmol (540 mg/dL) glucose solution
with infused starfruit leaves of varying concentrations; 200, 400, and 600
mg/kg. Samples were collected at 0, 15th, 30th, 45th, and 60th minute. The
sample was tested for glucose levels using spectrophotometry. Results: Test of
significance showed a significant difference between the control group and the
test group with p < 0.05. Conclusions: Starfruit leaves have a reduction
effect towards glucose absorption in the small intestines in Wistar strains
where the group using 600 mg/kg of infused starfruit leaves have the most
significant effect as compared to other groups.
Keywords: absorption; Averrhoa
carambola; glucose; infusion; intestine small
Author: Rifqi Y Muhammad,
Ramdan Panigoro, Julius B Dewanto
Journal Code: jpkedokterangg160320
