Mitochondrially-Encoded Adenosine Triphosphate Synthase 6 Gene Haplotype Variation among World Population during 2003-2013
Abstract: Adaptation and
natural selection serve as an important part of evolution. Adaptation in molecular
level can lead to genetic drift which causes mutation of genetic material; one
of which is polymorphism of mitochondrial DNA (mtDNA). The aim of this study is
to verify the polymorphism of mitochondrially-encoded Adenosine Triphosphate
synthase6gene (MT-ATP6) as one of mtDNA building blocks among tropic,
sub-tropic, and polar areas. Methods: This descriptive quantitative research
used 3,210 mtDNA sequences, taken from GenBank, as secondary data from 27
different populations. The data were grouped into 3 population groups based on
the climates of their location. After grouping, the sequences were then aligned
and trimmed using Unipro EUGENE, and analysed by Arlequin and MitoTool.
Results: Results demonstrated 21 haplotypes distributed among 3 populations with
variations between each climate population. In the tropic and sub-tropic
populations, the dominant haplotype is h1 while h6 is dominant in the polar
population. Conclusions: There is a variation of haplotype polymorphism between
tropic, sub-tropic, and polar climate population.
Keywords: climate; DNA;
genetic testing; mitochondrial; MT-ATP6
Author: Steven, Yoni F
Syukriani, Julius B Dewanto
Jounal Code: jpkedokterangg160322
