A 44 Year Old Man with Chronic Myeloid Leukemia and Mass at Right Lower Leg
Abstract: Chronic myeloid
leukemia (CML) is a clonal myeloproliferative disorder of primitive
hematopoetic stem cells that is characterized by overproduction of myeloid
series cells, splenomegaly, and leukocytosis. We reported a case of 44 years
old male with CML who complained about swelling right leg and pain for 3 month.
It had been diagnosed as CML for 3 years, and he took hydroxyurea but stopped
for a year due to economic problem. The results of clinical examination,
laboratory, biopsy, and radiology showed a result matched to CML with soft
tissue mass. The results of Fine Needle Aspiration Biopsy (FNAB) of fragmented histiocytes
leg mass, multinucleated giant cells, and atypical nucleated with a possibility
of fibroma with atypical nucleated cells. Magnetic resonance imaging (MRI)
showed multilocular lobulated soft tissue mass from the popliteal region to the
cruris dextra, cyst mass high protein dd/solid tumor with vascular encasement
and lesions in bone marrow replacement, and fluid collection on bursa
parapatella. The patient was treated with hydroxyurea and showed clinical
improvement and decreased mass size in the legs.
Keywords: Chronic myeloid
leukemia; CML; hydroxyurea; mass leg
Penulis: Ahadini Islamiah,
Shinta Oktya Wardhani
Kode Jurnal: jpkedokterandd170381
