SUPLEMENTASI TEPUNG PORANG (Amorphophallus muelleri Blume) SEBAGAI Nutraceutical DALAM MANAJEMEN DIABETES MELLITUS TIPE 2
Abstract: Diabetes is a group
of metabolic diseases characterized by hyperglycemia. Type 2 Diabetes is most
commonly type which accounts for 90-95% of those, resulting from defects in
insulin secretion and insulin action. Management of type 2 diabetes should
combine pharmacological therapy with both diet modification and increasing
physical activity. Nutraceutical was known to have important role. A kind of
Araceae family, Porang (Amorphophallus muelleri Blume), has a main content of
glucomannan. Glucomannan is a water-soluble polysaccharide, high fibers and low
calories. Various studies suggest the benefit effects of glucomannan in type 2
diabetes mellitus to improve blood glucose level and lipid profiles. Its
mechanism is postulated to be associated with the intrinsic physical effects of
soluble fiber in the gastrointestinal tract and fermentation by microflora in
the large intestine that trigger production of several gut hormones. Short
Chain Fatty Acids, product of fiber fermentation, can improve insulin
sensitivity through competition with free fatty acids and increasing expression
of GLUT 4 in insulin sensitive tissues. Therefore, glucomannan from Porang has
a great potential to be a nutraceutical for the management of type 2 diabetes
mellitus.
Penulis: Nurlaili Susanti
Kode Jurnal: jpbiologidd141089
