MEKANISME TERJADINYA INFLAMASI DAN STRES OKSIDATIF PADA OBESITAS
Abstract: Obesity is a
predisposing factor for metabolic syndrome that increases the risk of
development of chronic diseases such as type 2 Diabetes Mellitus and
atherosclerosis. Obesity is associated with a chronic inflammatory condition
with progressive infiltration of immune cells in the adipose tissue of obesity.
Adipose tissue is not only a triglyceride storage organ, but studies have shown
the role of white adipose tissue as a producer of adipokines. Besides
adipokines, also found several inflammatory mediators, such as interleukin-6
(IL-6). Adipokines have the function of regulating food intake, thus providing
a direct effect on weight control. It is played by leptin, which is working on
the limbic system by stimulating the uptake of dopamine, creating a feeling of
fullness. But these adipokines induces production of reactive oxygen species
(ROS), resulting in a process known as oxidative stress (OS). There are several
mechanisms in producing the oxidative stress . The first is the oxidation of
mitochondrial and peroxisomal fatty acid oxidation, which can generate ROS in
the oxidation reaction, whereas other mechanisms is over-consumption of oxygen,
which generates free radicals in the mitochondrial respiratory chain were found
together with oxidative phosphorylation in the mitochondria. High fat diet also
capable of generating ROS because it can alter the oxygen metabolism.
Penulis: ana rahmawati
Kode Jurnal: jpbiologidd141088
