Pengaruh Pemberian Gel Doksisiklin terhadap Jumlah Fibroblas pada Proses Penyembuhan Dermatitis Paederus akibat Racun Kumbang Tomcat (Paederus sp.) pada Mencit
Abstract: Paederus dermatitis
caused by rove beetle makes the tissue damage called dermonecrosis. The MMP on
pederin toxins from the symbiosis of rove beetle (Paederus sp.) and Pseudomonas
aeruginosa is supposed can delay the wound healing process. Doxycycline gel as
a MMP inhibitor is believed can accelerate the healing process. The purpose of
this study was to determine the effect of doxycycline gel on the healing
process of Paederus dermatitis by observing the number of fibroblasts as an
indicator. This study used 40 mice, were divided into four major groups, those
were normal control group, the negative control, treatment groups with
doxycycline gel 1% and 5%. Termination was performed on days 1, 3, 5, 7, and
15. Data was obtained by calculating the number of fibroblasts per field of
view, then processed in ImageJ and tested statistically with comparation test
of One Way Anova. The average number of fibroblasts per field of view in
treatment groups was higher. The peak occurred on day 7 and decrease on day 15.
It indicated that the topical administration of doxycycline gel on Paederus
dermatitis can accelerate healing process, showed by the increasing in average
number of fibroblasts per field of view.
Penulis: Silvi Ahmada Chasya,
Al Munawir, Erma Sulistyaningsih
Kode Jurnal: jpkesmasdd160096
