Pengaruh Pemberian Ekstrak Etanol Brokoli (Brassica oleracea) terhadap Kadar SGOT dan SGPT Tikus Wistar yang Diinduksi DMBA
Abstract: DMBA is a product of
incomplete burning which can cause free radicals in human. The metabolism of
DMBA by Cytochrome P450 in liver causes hepatocyte DNA damage and decrease
endogenous antioxidant. Broccoli contains flavonoid which can act as an
antioxidant by inhibiting formation of free radicals through hydrogen atom
donation to free radicals. This research aimed to analyze the effect of
ethanolic extract of broccoli on SGOT and SGPT of wistar rats induced by DMBA.
This research used 24 rats divided into six groups: control group, negative
control group, and four treatment groups with broccoli ethanolic extract of 250
mg/kgBW, 500 mg/kgBW, 1000 mg/kgBW, and 2000 mg/kgBW for 7 days. The SGOT and
SGPT levels of control group were 70,36 U/L and 33,97 U/L; negative control
group 107,16 U/L and 56,21 U/L; the first treatment 101,50 U/L and 49,33 U/L;
the second treatment 85,32 U/L and 43,67 U/L; the third treatment 84,11 U/L and
40,84 U/L; and the fourth treatment 81,28 U/L and 35,18 U/L. The result of One
Way Annova test for SGOT was p=0,012 while SGPT was p=0,003. In this study,
ethanolic extract of broccoli could protect hepatocyte by decreasing SGOT and
SGPT levels.
Penulis: Rizka Nuzula Wardani,
Elly Nurus Sakinah, Yudha Nurdian
Kode Jurnal: jpkesmasdd160095
