Uji Aktivitas Fraksi Diklorometana Ekstrak Metanol Bangle (Zingiber cassumunar Roxb.) sebagai Terapi Komplementer Malaria secara In Vivo
Abstract: World Malaria Report
reported that Malaria threats 40% of world population in six regions and ninety
seven endemic countries. This study aimed to investigate the activity of
dichloromethane fraction of Bangle as a complementary therapy of malaria in
vivo. This was true experimental laboratories study using 28 mice of Balb/c,
divided into seven groups. Five treatment groups were given five dose of
dichloromethane fraction of Bangle methanolic extracts as imunostimulant before
malaria infection and during malaria therapy by combining with malaria standard
therapy. K(+) group was given malaria standard therapy. K(-) group was not
given any therapy after infection. Inhibition percentage of malaria parasite in
K(-) was 0 and K(+) was 24,74%. The treatment group of 0,09 mg/grBW had the
highest inhibition percentage, as many as 88,19%. It declined by decreasing
dose of fraction. The result of pearson correlation showed very strong
correlation (r=0,880). The Ic50 value of dichloromethane fraction of Bangle
methanolic extract as a complementary therapy was 0,008 mg/grBW. In conclusion,
dichloromethane fraction of Bangle methanolic extract had immunostimulant
effect and antimalarial activity in vivo.
Penulis: Edda Rachmadenawanti,
Bagus Hermansyah, Yuli Hermansyah
Kode Jurnal: jpkesmasdd160094
