Pengaruh Ekstrak Albumin Ikan Gabus (Chana striata) terhadap Kadar IFN-γ Pasien Tuberkulosis Paru dengan Pengobatan Fase Intensif
Abstract: Pulmonary
tuberculosis is a respiratory infection disease caused by Mycobacterium
tuberculosis infection in lung tissue. Mycobacterium tuberculosis could inhibit
macrophage activation by inducing an increase of SOCS1 which can inhibit IFN-γ
signaling process. Meanwhile, IFN-γ production continues as long as Mycobacterium
tuberculosis still exist, so the IFN-γ levels stay high. This study aimed to
investigate the effect of albumin snakehead fish (Chana striata) extract to
decrease IFN-γ level. The study design was a quasy experimental design. The
study subject was 24 tuberculosis patients during intensive phase medication,
were divided into 2 groups. Experimental group was given 1500 mg/day albumin
snakehead fish (Chana striata) extract while control group was placebo for 30
days. This study showed that albumin snakehead fish (Chana striata) extraxt can
decrease significanly IFN-γ levels in the experimental group (p=0.006) but not
statistically signicant if compared with the decrease of control group
(p=0.061). It can be concluded that albumin snakehead fish (Chana striata) extract
in dose of 1500 mg/day had not able to decrease IFN-γ levels of pulmonary
tuberculosis patients during intensive phase medication yet.
Penulis: Henggar Allest
Pratama, Erfan Efendi, Rini Riyanti
Kode Jurnal: jpkesmasdd160091
