Pengaruh Stres Fisik terhadap Kadar Kreatinin Serum Tikus Wistar Jantan (Rattus norvegicus)
Abstract: Physical stress is a
condition that caused by severe physical activities which can increase free
radicals production causing oxidative stress. Oxidative stress causing the
organs failure include the kidney. It damage glomerulus causing decrease in GFR
and tubular cell damage causing cumulation of creatinine and raise creatinine
serum. This study investigated the difference of serum creatinine of male
Rattus norvegicus with physical stress and without physical stress. Ten male
Rattus norvegicus aged 2-3 months were divided into two groups : control and
treatment group. Control group without physical stress but treatment group was
given physical stress 30 minutes of swimming stress in the morning everyday for
10 days. The creatinine serum measured by Jaffe reaction. The normal range of
serum creatinine for Rattus norvegicus was 0,578-1,128 mg/dl. The result of
serum creatinine for control group was 0,52 mg/dl and treatment group was 0,62
mg/dl,both still in normal range. The analysis using Mann Whitney showed the
significance of 0,23 (p>0,05). We can conclude that there was no difference
of serum creatinine of male Rattus norvegicus with physical stress and without
physical stress.
Penulis: Putu Ratih Pradnyani
Dewi, Hairrudin Hairrudin, Rena Normasari
Kode Jurnal: jpkesmasdd160092
