Optimasi Hidroksipropil Metilselulosa dan Carbopol terhadap Moisture Content dan Laju Pelepasan Patch Ibuprofen In Vitro
Abstract: Ibuprofen is non
steroidal antiinflammatory drug (NSAID) of the propionic acid class which is
widely used for the treatment of rheumatoid arthritis. Ibuprofen patch is an
effective approach evading ibuprofen's adverse effect in the GI tract and first
pass effect. The function of polymer is to control the drug release from the
patch. The aims of this study were to determine the effect of hydroxypropyl
methylcellulose (HPMC) K4M and carbopol 934 combination on the moisture content
(MC), in-vitro drug release, and to obtain the optimum formula of those
polymers. Ibuprofen patch were prepared into three formulas based on simplex
lattice design with the ratio of HPMC K4M : carbopol 934, that were 1 : 0, 0.5
: 0.5, and 0 : 1. Design expert software was used to obtain the optimum formula
of both polymers. The results of this study showed that patch with HPMC K4M :
carbopol 934 (0.5 : 0.5) gave the best MC and the in-vitro drug release. The optimum
formula was HPMC K4M and carbopol 934 with the ratio of 0.5 : 0.5.
Penulis: Kristine Dwi
Puspitasari, Dwi Nurahmanto, Lidya Ameliana
Kode Jurnal: jpkesmasdd160090
