PENGUJIAN TOKSISITAS AKUT ORAL DAN DERMAL PADA BIOLARVASIDA METARHIZIUM ANISOPLIAE TERHADAP TIKUS PUTIH SPRAQUE DAWLEY
ABSTRACT: Acute oral and
dermal toxicity test against white rats was conducted to determine the toxicity
and side effects of bio-larvacide (Metarhizium anisopliae crude extract) on
humans. In the oral test used a maximum dose 5000 mg/kg and dermal testing used
a maximum dose of 2000 mg/kg. Dose treatment and control tested to 5 Spraque
Dawley male rats. The results showed that oral treatment with a dose of 5000
mg/kg did not cause mortality and did not cause changes in anatomic pathology
of viceral organs. In the dermal treatment with a dose of 2000 mg/kg did not
cause mortality and did not cause changes in anatomic pathology of viceral
organs. Based on these results LD50 acute oral M. anisopliae biolarvacide above
5000 mg/kg and the acute dermal is above 2000 mg/kg. It was therefore concluded
that the formulation of Metarhizium anisopliae biolarvasida classified as not
hazardous when used in accordance with the recommendation of the class I (WHO,
2003).
Penulis: Deni Zulfiana
Kode Jurnal: jpbiologidd141009
