Senyawa Goitrogenik dalam Bahan Makanan (Goitrogenik Substances in Foodstuffs)
ABSTRACT: It has
been known for
a long time
that iodine deficiency
results in enlarged
thyroid gland (goiter).
However, iodine supplementation
alone frequently fails to eliminate goiter in particular area. At present,
experts realized that many agents interact with
iodine deficiency in producing goiter. Agents that cause goiter are
known as goitrogens. Several goitrogens are found in the foodstuff. Our study
in Ngargoyoso sub-district revealed that several foods containing suspected
such substances are consumed by school children. They are soybean cake, tofu,
onion, tomato, cassava leaves, cabbage, cassava tuber and broccoli. Soybean
cake and tofu are made from soybean containing isoflavone which exerts anti
-thyroid activity in rats. Onion contains allyl-sulfides. Tomato, cassava
leaves, and broccoli contain pigments with antioxidant moiety and anti thyroid
activity. Cabbage contains isothyocyanat, a potent anti thyroid in rats and
rabbits. Cassava contains linamarin. The study was a recalled study using food
frequency questionnaire. In order to prove the goitrogenic activity in those
foods an In-Vitro Assay or In-Vivo Assay should be carried out. Since plants
grown in certain areas are influenced by soil and water, it is reasonable to
measure anti thyroid activity using plants grown locally. This paper will
describe those assays and suggest the most applicable in Indonesia.
Penulis: YULIA LANTI RETNO
DEWI
Kode Jurnal: jpbiologidd150299
