Sintesis asam 2-(2-(4-kloro-N-(2,6-Diklorofenil)benzamida) fenil)asetat sebagai salah satu turunan diklofenak yang merupakan kandidat obat penghambat COX (siklooksigenase)
Abstract: Sodium diclofenac is
an analgetic agent as an antimetabolite that used for treating pain. Several
compound as a derivative diclofenac has been synthesis for increase its
activity and reduce side effect. 2-(2-(4-Chloro-N-(2,6-dichlorophenyl)
benzamido)phenyl)acetic acid is a derivate of Sodium diclofenac that
synthesized for development new drugs. Synthesis
2-(2-(4-Chloro-N-(2,6-dichlorophenyl) benzamido)phenyl)acetic has benzoylation
reaction between Sodium diclofenac and 4-Chlorobenzoil Chloride to give the
target compound (2-(2-(4-Chloro-N-(2,6-dichlorophenyl) benzamido)phenyl)acetic
acid).This compound has been purified by Column Chromatography and give yellow
color with melting point 143-145oC and then fix identification by H-NMR 400 MHz
and KBr FTIR. 2-(2-(4-Chloro-N-(2,6-dichlorophenyl) benzamido)phenyl)acetic
acid can synthesized and resulted 8.39 % of yield.
Keywords: Sodium diclofenac,
2-(2-(4-Chloro-N-(2,6-dichlorophenyl)benzamido)phenyl)acetic acid, pain
Penulis: Wahyu Novandari
Herdiyanti, Ayik Rosita Puspaningtyas, Ika Oktavianawati
Kode Jurnal: jpkesmasdd140365
