Pengaruh Trietanolamin terhadap Karakteristik Fisika Kimia dan Laju Pelepasan Ibuprofen dalam Sediaan Gel Dispersi Padat Ibuprofen-PEG 6000
Abstract: The present research
has been undertaken with the aim to develop a topical gel formulation of
ibuprofen which would avoid side effects of ibuprofen in oral administration.
In this study, ibuprofen was made in solid dispersion form with PEG 6000
polymer composition 1 : 1.5 by fusion method. Solid dispersions aims to improve
the solubility of ibuprofen. Triethanolamine as an alkalizing agent was added
with different concentration in each gel formula which are 1 %, 2 %, and 4 %.
They were evaluated for physicochemical properties such as organoleptic, pH,
viscosity and in vitro drug release. Based on this research, it can be
concluded that the different concentration of triethanolamine doesn’t give the
significant effect on viscosity, nonetheless there is a significant effect on
pH and dissolution rate of ibuprofen. It is obtained that the highest
dissolution rate is F3 with a flux as 216.93 μg/cm2.minutes.
Penulis: Tanfidz Alishlah,
Budipratiwi Wisudyaningsih, Lidya Ameliana
Kode Jurnal: jpkesmasdd140364
