AGREEMENT BETWEEN ULTRASONOGRAPHY AND HISTOPATOLOGIC FINDINGS IN DIAGNOSING RETINOBLASTOMA
ABSTRACT: Retinoblastoma is a
rare eye tumor of childhood that represents the most common intraocular
malignancy of infancy and childhood. Diagnosis of retinoblastoma are based on
ophthalmological examination and imaging, including ultrasonography (USG). In a
typical case of retinoblastoma, it will provide a nearly pathognomonic picture
with cottage-cheese calcification, with density higher than the sclera and high
internal reflectivity in USG findings. Histopathologic examination is a gold
standard formalignany cases and Flexner-Wintersteiner cells is a pathognomonic sign.
The aim of this study is to determine the value of an agreement test comparing
USG as a preoperative diagnostic tool with histopatologic examination in
diagnosing retinoblastoma. This study was an observational agreement test. All
of the patients with clinically suspected intraocular lession were examined
with USG followed by surgery and histopathologic examination in Eye Clinic of
Dr. Sardjito Hospital, Yogyakarta. The result of USG examinationswas
interpreted by one eye oncologist and the histopathologic readingwas performed
by one anatomical pathologist. Data were analyzed to determine the agreement
value. Thirty three eyes, 21 eyes were retinoblastoma suspected and 12 eyes
were non-retinoblastoma suspected based on USG examination), were observed in
this study. One eye (3.03%) was false positive case and 1 was false negative
case. The Kappa value of agreement test was 0.87. In conclusion,
ultrasonography of the eye as a pre-operative diagnostic tool had an excellent
agreement compared with histopathological examination as a gold standard in
retinoblastoma.
Author: Fitria Natliani
Journal Code: jpkedokterangg110224
