Uji Sitotoksisitas Ekstrak Daging Dan Biji Buah Phaleria macrocarpa (Scheff.) Boerl Terhadap Sel Mononuklir Normal Perifer Manusia
ABSTRACT: There were many
research on Phaleria macrocarpa (Scheff.) Boerl. fruit for its activity as
possible anticancer. However, there wasn't investigation that P. macrocarpa
seed and fruit meat ethanol extract effect to normal cell. The research was
conducted to identify the ethanol extract of P. macrocarpa for cytotoxic
activity against mononuclear perifer normal cell of human blood. The research
comprised several sections including P. macrocarpa seed and fruit meat
maceration with ethanol, and the cytotoxic activity test against mononuclear
normal cell. The results showed that the ethanol extract of P. macrocarpa fruit
meat and seed was slightly toxic against mononuclear normal cell with the LC50
of 3817.54 μg/mL and 1349.29 μg/mL respectively. Tamoxifen and 5-fluorourasil,
anticancer drugs were extremely toxic against mononuclear normal cell giving
LC50 of 3.52 μg/mL and 4.05 μg/mL. The ANOVA f-test (P<0,05) showed that
seed of ethanol has higher cytotoxic activity than fruit meat extract. Extract
no cytotoxic activity difference between tamoxifen and 5-fluorourasil.
Penulis: Endang Astuti, Deni
Pranowo, Santi Dwi Puspitasari
Kode Jurnal: jpkimiadd060068
