Studi Mekanisme Reaksi Pada Sulfonasi Alkaloid Papaverine Dengan GC-MS dan FT-IR
ABSTRACT: The aim of this
research was to prove theoretical mechanism reaction on the sulfonation of
papaverine alkaloid and the result could be used as a reference on the
transformation of these alkaloid to the other derivatives. Theoriticaly
sulfonation of papaverine (1) by HO-SO2Cl could produced papaverine sulfonyl
chloride (1a). The formation of this product was analyzed by analytical thin
layer chromatography GC-MS, and FT-IR. These analysis showed the formation of
product (1a) more favorable than the other. Tlc showed product (1a) less polar
than papaverine, and supported by GC-MS and infrared which showed molecular ion
at m/z 412 due to the presence of -SO2Cl and vibration at 1153,4 dan 1265,2
Cm-1 due to absorption of sulfonyl group.
Penulis: I Made Sudarma
Kode Jurnal: jpkimiadd070085
