Analisis Hubungan Struktur – Aktivitas Antioksidan dari Isoeugenol, Eugenol, Vanilin dan Turunannya
ABSTRACT: Structure Activity
Relationship (SAR) technique between the theoretical parameters and antioxidant
activities of isoeugenol, eugenol, vanillin and their derivatives as Mannich
reaction products, have been analyzed. Antioxidant activities were examined by
oxidation reaction of oleic acid at 60 °C with b-carotene methods, whereas
theoretical parameters of the activities were determined by calculating Bonding
Dissociation Enthalpy (BDE) and net charge of oxygen atom(-OH) using AM1 semi
empiric methods. The result from both test showed in the following orders: BHT
> Mannich product of isoeugenol > isoeugenol > Mannich product of
eugenol > eugenol > Mannich product of vanillin > vanillin. The
antioxidant activities increase with small the BDE value and high the net
charge. Electron donating groups will increase the antioxidants activity with
lowering the BDE value and increasing the net charge, while
electron-withdrawing groups will decrease antioxidants activity.
Penulis: Nur Aini, Bambang
Purwono, Iqmal Tahir
Kode Jurnal: jpkimiadd070084
