Reaksi Subtitusi Nukleofilik Terhadap Ion Sianida dan Metoksida terhadap Basa Mannich Kuarterner dari Vanilin
ABSTRACT: The nucleophilic
substitution reaction to quaternary Mannich base from vanillin has been
investigated. Mannich reaction to vanillin was carried out by refluxing mixture
of vanillin, formaldehyde and dimethyl amine. Quaternary ammonium halide salt
was obtained from reaction of Mannich vanillin base with methyl iodide in THF
solvents and yielded 93.28%.
Nucleophilic substituion to the halide salts with cyanide nucleophile produced
4-hidroxy-3-methoxy-5-(cyano)methylbenzaldehyde in 54.39% yield, with methoxyde
ion obtained 4-hidroxy-
3-methoxy-5-(methoxy)-methyl-benzaldehide in 67.80% yield. The nucleophilic
substitution reaction showed that substituen of trimethylamino quaternary
Mannich base can act as a good leaving on nucleophilic reaction substitutions.
Penulis: Bambang Purwono,
Estiana E.P Daruningsih
Kode Jurnal: jpkimiadd070083
