Sintesis p-Metoksisinamil p-Metoksisinamat dari Etil p-Metoksisinamat Hasil Isolasi Rimpang Kencur (Kaempferia galanga L) sebagai Kandidat Tabir Surya
ABSTRACT: Synthesis of
p-methoxy-cynnamil-p-methoxy-cinnamate, (PMS)2O from ethyl-p-methoxy-cinnamate
(EPMS) from dry rhizome of kaempferia galanga L as sunscreen compound have been
done. Isolation of EPMS was done by percholation using ethanol 96 % and
recrystallitation using methanol to have 2.2 % yield. Hydrolysis of EPMS using
alcoholic KOH resulted methoxycinnamic acid (APMS) of 90.26 % yield. Reduction
EPMS using lithium aluminium hydride in dry ether would give p-methoxycinnamoyl
alcohol (PMS-OH) of 41.98 % yield. Then reaction of p-methoxycinnamoyl chloride
(PMS-Cl) and PMS-OH in chloroform would produce p-methoxycinnamoyl
p-methoxycinnamate ((PMS)2O) of 1.77 % yield. All compound were identified by
TLC and several spectrometry methodes i.e. U.V Vis, IR, 1H-NMR and GC-MS.
Penulis: Titik Taufikkurohmah
Kode Jurnal: jpkimiadd050037
