Sintesis Analog L-α-metil-Dopa dari Eugenol
ABSTRACT: Synthesis of analog
L--metil-Dopa from eugenol has been achieved through conversion of allyl group
to ketone, followed by reaction with NH3 and KCN and by hydrolisis. The
addition reaction of methyleugenol with formic acid yield methyleugenyl formate
(60,69%). The hydrolis of methyileugenylformate with KOH in aqaueous-ethanolic
solution produced methyleugenyl alcohol (73,68%). The oxidation of
methyleugenyl alcohol with PCC yield methyleugenyl ketone (67,71%). The
reaction of methyleugenyl ketone with NH3 and KCN yield
D,L--amino--(3,4-dimetoxybenzyl) propionitril (84,14%). The hydrolisis of
D,L--amino--(3,4-dimetoxybenzyl) propionitril with concentrated hydrochloric
acid gave Analog L--metil-Dopa as a main target (91,98%). The structure
elucidation of these products were analyzed by FTIR, 1H-NMR, 13C-NMR and MS
Penulis: Hanoch J Sohilait,
Hardjono Sastrohamidjojo, Sabirin Matsjeh, J Stuart Grossert
Kode Jurnal: jpkimiadd050038
