STUDI SISTEM DISPERSI PADAT GLIKLAZID MENGGUNAKAN POLIVINIL PIROLIDON K-30 (PVP K-30) DAN TWEEN 80
Abstrak: Solid dispersions of
gliclazide were prepared by solvent evaporation method using PVP K-30 and Tween
80 as dispersion carriers. The
physicochemical characteristics of solid dispersions were evaluated
using microscopic analysis, X-ray diffraction, differential thermal analysis,
determination of recovery, and dissolution rate test. Difractogram X-rays
showed the physical interaction between the drug (gliclazide) and carrier (PVP
K-30 and Tween 80), and polymorphic transformation occured during the evaporation
of solvent in the preparation of solid dispersion. Thermogram DTA showed that
the components of PVP K-30 and Tween 80 used affected the position of
endothermic peak and peak sharpness. Determination of gliclazide in the
recovery of solid dispersion was done using derivative spectrophotometry. Solid
dispersion of gliclazide-PVP K-30-Tween 80 prepared in this study were found to
have higher dissolution rates than pure gliclazide.
Penulis: Auzal Halim, Aulia
Shilvi, Erizal Zaini
Kode Jurnal: jpfarmasidd110066
