EFEK ANTIINFLAMASI FRAKSI HEKSAN DAN FRAKSI ETIL ASETAT DAUN ALPOKAT (Persea americana Mill.) PADA TIKUS (Rattus norvegicus) PUTIH JANTAN
Abstract: Avocado (Persea
Americana, Mill) has been used traditionally to cure disease but the effect has
not proven scientificaly. This study reports the determination of anti
inflammation effect of ethyl acetate
fraction and hexane
fraction of avocado
leaves at various
dose : 100,
200 and 400 mg/KgBW respectively. Inflammation was
induced by using Paw edema method with induction of 1% carrageen 0,5 ml.
Phenylbutazone at dose 9 mg/KgBW was used as positive control, while 1% sodium
CMC given 1 hr before induction was used as negative control. The edema volume was
determined at one hour interval for 5 hours, and percentage of inhibition was
then calculated. Result indicated that
the ethyl acetate
and the hexane
fractions of avocado
leaves at doses
100, 200, and 400
mg/KgBW showed significant
anti-inflammation effect (p<0.05).
The best effect was given by the ethyl acetate
fraction at dose 400 mg/KgBW.
Penulis: Sekolah Tinggi Ilmu
Farmasi Riau
Kode Jurnal: jpfarmasidd110067
