Pengaruh Pemberian Infusa Herba Sambiloto (Andrographis Paniculata Nees) Terhadap Glibenklamid Dalam Menurunkan Kadar Glukosa Darah Tikus Putih Jantan yang Dibuat Diabetes
Abstract: Many diabetics perform
self-medication with antidiabetic herbs and synthetic drugs with the aim to
obtain a synergistic or additive effects without informing their primary
physician, such as the use of creat and glibenclamide. This research was
carried out to know the impact of creat
herb infusion on glibenclamide in bwering blood glucose levels on diabetic male
albino rats. This study used 24 male Sparague-Lawley rats, which are divided
into 6 groups, normal control and diabetic control were given 0,5% CMC solution
I ml/200 g bw of rat, glibenclamide
control were given glibenclamide suspension 0,9 mg/200 g bw of rat, creat
control were given creat herb infusion 50 mg/200 g bw of rat, and 2 interaction
groups were given creat herb infusion in 2 variant doses (50 and 100 mg/ 200 g
bw of rat) and glibenclamide suspension 0,9 mg/200 g bw of rat, each of them
were administrated orally. All of groups were induced with alloxan 32 mg/ 200 g
bw of rat except normal control. Blood glucose was measured by 0-toluidine
method at 2 hours and 4 hours after administration. The result showed that the
creat herb infusion at 100 mg/200 g bw gave significant impact on glibenclamide
in lowering blood glucose levels week after administration.
Keywords: alloxan,
Andrographis paniculata Nees, creat herb infusion, diabetes mellitus,
glibenclamide
Penulis: Santi Purna Sari
Kode Jurnal: jpfarmasidd120137
