PENGARUH KONSENTRASI AMILUM JAGUNG PREGELATINASI SEBAGAI BAHAN PENGHANCUR TERHADAP SIFAT FISIK TABLET VITAMIN E UNTUK ANJING
Abstract: Corn starch is
widely used as excipient in the manufacture of tablets. Native corn starch that
have a bad flowability were modificated into pregelatinized corn starch to
increase it flowability. The aim of this research was to know the effect of the
use of pregelatinized corn starch as disintegrant on the physical properties of
Vitamin E tablets for dogs with direct compression method.
Pregelatinized corn starch is made by heating the suspenssion of starch
at 550 C for 10 minutes and then dried. Pregelatinized corn starch is used as a
disintegrants of vitamin E tablets for dog which made by direct compression
with three variation of pregelatinized corn starch concentration, that is 5%;
7.5%; and 10%. Quality of resulting tablet are known through the hardness test,
friability test, and disintegrating time test. The result from the research
will be analysed by One-way ANOVA method.
The result showed that the use of pregelatinized corn starch as
disintegrant at concentration 5%; 7.5%; and 10% with direct compression method
do not give an effect to physical properties of the tablets and do not meet the requirements of a good
tablet.
Keywords: corn starch,
pregelatinized starch, disintegrant
Penulis: Komang Ayu Mariyani,
Cok. Istri Sri Arisanti, Eka Indra Setyawan
Kode Jurnal: jpfarmasidd120155
