PENGARUH RASIO AMILUM: AIR DAN SUHU PEMANASAN TERHADAP SIFAT FISIK AMILUM SINGKONG PREGELATIN YANG DITUJUKAN SEBAGAI EKSIPIEN TABLET
Abstract: Cassava starch is
the common type of starch with enormous application in pharmaceutical industries.
However, cassava starch has poor compressibility and flowing hard. Therefore,
it is need to be modified. One of starch modification methods is physical
method like gelatinization because easier than the other method. A good
pregelatin starch will be formed by the addition of water and use the proper
temperature. This research aimed todetermine the effect ofratio
starch:waterandheatingtemperature of cassavastarchtowardphysical characteristic
ofpregelatinized cassavastarchintendedasa tabletexcipient.
This research was conducted through several stage. First, the manufacture
of pregalatinized cassava starch by using ratio starch:water that are 1:0,5 ;
1:0,75, 1:1 and heating temperature are 50°C ; 55°C ; 60°C. Furthermore,
cassava starch and pregelatinized cassava starch preliminary tested. Starch
which meets the standard then tested their physical properties including
moisture testing, particle size distribution test, flow properties test dan
compressibility test. Starch with physical properties that meet the
requirements then compressed with direct compression method and tested. Testing
includes weight uniformity, hardness, friability and disintegrant time. Data
were analyzed with one-way ANOVA and LSD with 95% confidence level.
The result indicated, the addition of water and heating temperature gives
a significance influence (P<0,05) toward the flow characteristic and
compressibility of pregelatinized cassava starch. Increasing the amount of
water and heating temperature causes decreasing of compressibility. Decreasing
of compressibility make flow properties is better. Based on physical properties
of test criteria tablet, then selected ratio 1:1 (50°C) as selected formula for
tablet excipient direct compression method.
Penulis: Kadek Lenny Karisma
Sari, I G.N. Jemmy Anton Prasetia, Cok. Istri Sri Arisanti
Kode Jurnal: jpfarmasidd120156
