HUBUNGAN KADAR FIBRINOGEN PLASMA DAN MIKROALBUMINURIA PADA PENDERITA DIABETES MELLITUS TIPE 2
ABSTRACT: Increase of
fibrinogen concentration in type 2 diabetic patients is an indicator for
vascular inflammation, endothelial dysfunction. Hyperfibrinogenemia is a strong
marker and independently for atherosclerosis. Beside that, hyperfibrino
-genemia can precede macro and microvascular complication. In type 2 diabetic,
microalbuminuria is early marker for diabetic nephropathy and show that there
is endothelial dysfunction. Microalbuminuria not only useful to predict renal
damage, but also useful to predict cardiovascular damage. Microalbuminuria is a
marker for endothelial dysfunction. To know the correlation between increase of
fibrinogen concentration and microalbuminuria in type 2 diabetic patients. The
study was performed in Dr. M. Djamil central Hospital by using cross sectional method
and consecutive random sampling. Sample were type 2 diabetic patients included
criteria were measured albumin/ creatinine ratio and
the patients was
divided in 2
group, that is
group A (normoalbuminuria) and
group B (microalbuminuria) with
total sample were 90 patients. Each group were performed measurement of
albumin/ creatinine ratio, random glucose concentration, and fibrinogen
concentration in plasma. In group A, we found the average of albumin/
creatinine ratio is 6.6 μg/mg and in group B is 107.5 μg/mg. The average of
random glucose concentration in group A is 181.3 mg/dl, and in group B is 204
mg/dl and the difference of concentration is not significantly (p > 0.05).
The average of fibrinogen concentration in group A is 383.5 ± 104.6 mg/dl, and
in group B is 467 ± 79 mg/dl. Increasing fibrinogen concentration in group B is
higher than group A and the increasing is significantly statistical difference
(p <0.05). In this study we also founded the positive correlation between
concentration of fibrinogen plasma and albuminuria ( r = 0.036, p =0.0004). In
type 2 diabetic patients with normoalbuminuria has been increased fibrinogen
concentration, and the increasing of fibrinogen concentration in type 2
diabetic patients with microalbuminuria is higher than type 2 diabetic patients
with normoalbuminuria. There are positive correlation between fibrinogen plasma
concentration and albumin/creatinine ratio.
Penulis: Rikarni, Lillah,
Yoesri
Kode Jurnal: jpkedokterandd0700266
