Potensi Antioksidan sebagai Antidiabetes
Abstract: Diabetes mellitus
(DM) is a syndrome that is marked by elevated
blood sugar level. DM is categorized
into two types: type 1 DM is called
insulin-dependent diabetes mellitus (IDDM) and type 2 DM is called non-insulin-dependent diabetes
mellitus (NIDDM).
Glucose can be oxidized before or after bound with protein (glycated
protein), producing Reactive Oxygen Species (ROS). Diabetic patients indicate
lipid peroxide and Thiobarbituric Acid Reactive Subtances (TBARS) plasma levels that are higher than
normal individuals. The combination of glycation and glucose oxidation forms
AGEs (Advanced Glycogen End-products). Glycated protein and AGEs modified
protein can cause oxidative stress by
releasing O2*- ,H2O2 and carbonyl
toxic can damage protein.
Many kinds of plants contain
active compounds that can inhibit carbohydrate hydrolysis and glucose
absorption, regenerate β-cells so as to increase the release of insulin,
inhibit aldose reductase and control the glucose level. Synthetic as well as
natural antioxidant compounds from various plants can control glucose level and
inhibit diabetic complications. Polyphenolic active compounds in plants have antioxidant and hypoglycemic
activities.
To reduce the amount of type 1 DM patients it is necessary to change the
life style, among others by consuming
enough vegetables and fruits as antioxidant sources.
Penulis: Wahyu Widowati
Kode Jurnal: jpkedokterandd080023
