Peran Gen p63 dalam Regulasi Proliferasi Sel
Abstract: p63 gene that exits
in chromosome 3q27-28 has two promoters and three different C ends, namely a,
b, and g so that the transcription of p63 gene produces 6 variants. Various
researches show that p63 gene plays a role in inducting the stoppage of cell
cycles in the form of G1 arrest and G2 arrest. The products of p63 gene also
have a role in activating the extrinsic/death receptor-mediated apoptosis
pathway and the intrinsic/mitochondria-mediated apoptosis pathway.
Understanding of the role of p63 gene in regulating cell proliferation and the
synergic effect of p63 and chemotherapy medicines is essential to develop
strategies for cancer therapy.
Penulis: Teresa Liliana
Wargasetia
Kode Jurnal: jpkedokterandd080022
