Perbandingan Kejadian Neutropeni dan Neuropati Perifer Akibat Kemoterapi Adjuvan Paclitaxel – Carboplatin antara Paclitaxel Infus 3 Jam dengan Paclitaxel Infus 24 Jam pada Penderita Kanker Ovarium Stadium I–IV
ABSTRACT: The objective of
this research is to compare the difference of neutropeni with peripheral
neuropathy incident, after administration of paclitaxel infuse 3 hours and 24
hours in adjuvant therapy with paclitaxel-carboplatin in patient with ovarial
carcinoma. This research is using experimental research with samples that was
randomized after consecutively recruited based on inclusive criteria. Before
and every after chemoteraphy performed NCS and differential count
laboratories’s test and then analyzed with T-test and Chi-square test. From
three times administration of paclitaxel 3 hours-carboplatin group, the
incident of neutropeni after first until third chemo was 20%, 30%, 30%,
respectively; and the incident of peripheral neuropathy was 30%, 60%, 50%, respectively.
From Paclitaxel 24 hours-carboplatin group the incident of neutropeni after
first until third chemo was 40%, 50%, 40%, respectively; and the incident of
peripheral neuropathy was 20%, 20%, 20%, respectively. The statistic result was
p > 0,05. The conclusion of this research is no significant difference in
neutropeni and peripheral neuropathy incident on two study group.
Keywords: Neutropenia, peripheral neuropathy,
paclitaxel, carboplatin, ovarial carcinoma, neuro conduction study
Penulis: Primandono Perbowo,
Brahmana Askandar T, Sunjoto, Ratna D Soebadi, Achmad Basori
Kode Jurnal: jpkedokterandd080003
