Perbandingan Kadar Brain Derived Neurotrophic Factor (BDNF) Serum Tali Pusat Bayi Baru Lahir Antara Ibu Hamil yang Mendapat dengan Tidak Mendapat Docosahexaenoic Acid (DHA)
ABSTRACT: Brain Derived
Neurotrophin Factor (BDNF) is a protein that is abundant in brain and
peripheral nerve. It affects neuron development, growth and survival. The
purpose of this study to compare the level of BDNF in human umbilical cord
blood from newborns between intervention and non intervention group to the
Docosahexaenoic Acid (DHA) during pregnancy. Design of this study was
analytical and experimental study, randomized controlled, double blind
controlled trial. The sample includes low risk pregnancy in 32 weeks of
gestational age, that were randomly divided into two groups. The intervention
group consumed soft gel capsule DHA/EPA 214/20 mg once daily until delivery. In
both groups, stressor rating scale and eating were analyzed. After delivery the
perinatal outcome were analyzed. The levels of BDNF newborn umbilical cord
blood were measured by ELISA method. There were no differences in perinatal
outcome from the two groups. Statistically, the level of BDNF in newborns
umbilical cord blood of non intervention group was not significantly different
from intervention group (10,259.87 ± 3,875.392 : 9,430.73 ± 2,910.077, p =
0.513). There is no significant differences of BDNF level of newborns umbilical
cord blood between intervention group and non intervention group.
Penulis: Elli Saur Mauli
Gultom, Hermanto Tri Joewono, Margarita M. Maramis
Kode Jurnal: jpkedokterandd080004
