Rasio Ekspresi Protein Bcl-2/Bax dan Perubahan Kelenjar Endometrium Rattus novergicus sebagai Model SOPK dengan Terapi Flutamide dan Edroxyprogesteron Asetat
ABSTRACT: The objective of
this research is confirming difference in Bcl-2/Bax expression ratio,
endometrial gland count after administration of flutamide, medroxyprogesterone
acetate and placebo in Rattus novergicus strain Wistar hiperandrogen as a PCOS
model. The research was taken place at Animal Test and Pathology Anatomy
Department in Veterinary Faculty, Airlangga University, November 2007 until
January 2008 period, as approved by Animal Research Ethics Commitee, Veterinary
Faculty, Airlangga University. The design was experimental research with
randomized post test only control group design. Sample are consecutively
recruited based on inclusive criteria and analyzed with Anova test as well as
double comparation test using LSD (Least Square Difference). The result are
from three treatment groups Rattus novergicus strain Wistar hyperandrogen as
SOPK models were found mean ratio of Bcl-2/Bax expression in P2 group
(flutamide administered) is lower compared to P1 (placebo) and P3
(medroxyprogesterone acetate administered) (P1; 1.9 0.3, P2;
1.06 0.4, P3; 1.2 0.2, p < 0.0001). Mean of endometrial gland count in
P2 group is lower compared to other group (P1; 8.5 0.3, P2; 5.4 0.2, P3; 6.4 0.3, p < 0.0001). The conclusion is
we found significant difference in Bcl-2/Bax expression and endometrium gland
count on all three study group. Endometrium Hyperplasia is lower on P2 group
(flutamide administered) compared to P3 group (MPA administered).
Keywords: PCOS, endometrium
hyperplasia, flutamide, medroxyprogesteron acetate, Bcl-2/Bax expression, endometrium gland count
Penulis: Laurens David Paulus,
Budi Santoso, Widjiati
Kode Jurnal: jpkedokterandd080005
