Peran Molekul HLA dalam Proses Transplantasi Sel Punca
Abstract: Human Leukocyte
Antigen (HLA) is the most
important factor in
determining the histocompatibility between
the donor and
the recipient in
transplantation. HLA is
a membrane-bound glycoprotein molecule
encoded by several
genes within chromosome
6. HLA can
be differentiated into Class
I (HLA-A, HLA-B,
and HLA-C) and
Class II (HLA-DP,
HLA-DQ, and HLA-DR).
The identification of these HLA molecules can be carried out by a
serology method and a DNA amplificationbased method. Lately, therapies in
regenerative medicine using stem cells have attracted much attention. Among
various sources of stem cells, umbilical cord blood has shown a unique property
through its low immunogenicity
profile. This feature
facilitates umbilical cord
blood stem cell
to become a
potential candidate to be used in a wider range of recipients even with
partial match HLA. A good understanding in the
mechanisms of antigen
recognition through HLA
is clearly required
to choose the
best strategy in transplantation.
Penukis: Melina Setiawan,
Caroline Tan Sardjono
Kode Jurnal: jpkedokterandd090097
