Etiologi Infertilitas pada Pria Akibat dari Mutasi DNA Mitokondria (mtDNA)
Abstract: Infertility has
affected about 10–15 per cent married couples. Almost half of infertility cases
have been attributed to men with low sperm motility (asthenozoospermia), low sperm count (oligozoospermia), and abnormal sperm morphology (teratozoospermia). Sperm motility is one of the major
determinants of male fertility and
is required for
successful fertilization. Mitochondrion
and mitochondrial DNA (mtDNA)
play an important
role in a
variety of physiological
processes. The mitochondrial
function is controlled by
a collaboration of nDNA and mtDNA. The accumulation of mtDNA
mutations has been suggested to be an important contributor to human aging and
degenerative diseases, and it can also impair the formation of sperm
dysfunction. As mitochondria supply energy by oxidative phosphorilation system (OXPHOS), any
mutation in mtDNA
will disrupt ATP
production and thus
result in an
impaired spermatogenesis and flagellar
movement. More than
100 point mutations
have been known
to be associated with
various human mitochondrial
diseases, but so
far only a
few studies have
reported mutations in mtDNA
of the spermatozoa.
An mtDNA mutation
will comprise point
mutation, microdeletion, multiple deletion, translocation, and
haplogroup mtDNA.
Penulis: Sri Utami
Kode Jurnal: jpkedokterandd090098
