Aspek Onkologi Human Papillomavirus
Abstract: Papillomaviruses are
a diverse group of DNA-based viruses that may infect the skin and mucous membranes of
humans and a
variety of animals.
There are over
100 different human
papillomavirus(HPV) types that
have been identified.
Human papillomavirus (HPV)
is a causal
factor in the development of cervical cancer. However,
the HPV's mechanism of carcinogenesis has not been completely identified. The
possibility of evolving
HPVs into the
direction of malignancy
will depend on
several factors, i.e. the type of the virus, the host and the
environment, all of which are able to modify the course of HPV infection. Based
on the epidemiological classification, HPVs can be divided into the high-risk
and low-risk types. The
high-risk types have
a marked tendency
to integrate in
the host genome.
The integration process may cause the interruption of E2 gene, which
has the consequence of losing its
control over E6 and E7 expressions. Moreover,
E6 and E7 products will interact with and inhibit the function of the
cellular tumor suppressor proteins (p53 and pRB).
Penulis: Djaja Rusmana
Kode Jurnal: jpkedokterandd090099
